Fudan University Journal of Medical Sciences

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Radiological imaging evaluation of children's intracranial central nervous system malformations in Xigaze city

Ciren DAWA, Guojie CIREN, Guo-fu ZHANG, Ji-mei WANG, He ZHANG

Fudan University Journal of Medical Sciences, 2024, 51(04): 608-613. DOI: 10.3969/j.issn.1672-8467.2024.04.021

Age group	With primary malformation （n=22）	With secondary malformation （n= 14）	P
≤ 1 year			0.332
Normal	0	1
Death		3	5
Neurological sequelae	1	3
Loss	3	3
1-3 years			-
Normal	0	0
Death	0	0
Neurological sequelae	4	0
Loss	3	0
＞3 years			0.759
Normal	0	0
Death	0	0
Neurological sequelae	3	1
Loss	5	1

Tab 3 The outcomes comparison between the congenital and secondary malformation groups across the age level

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Tab 1 Clinical indications and the final prognosis for all the included 36 cases
Tab 2 Imaging findings in the included 36 cases underwent both CT or MRI examination
Fig 1 Imaging demonstrations of CNS malformations in the ≤ 1-year-old group A: CT revealed lissencephaly in a one-month-old infant; B: Dandy-walker malformation was found on sagittal MRI in a 1-month-old infant who died 3 months after birth; C: The cystic changes in bilateral cerebral parenchyma was found on MRI in a 2-month-old infant; D: The heavy hydrocephalus was found on CT in a 2-month-old infant who died after one-month treatment; E: The extent subdural effusion was found on CT for a 10-month-old infant who died one year after birth.
Fig 2 Imaging demonstrations of CNS malformations in the 1- to 3-year-old group and>3-year-old group A: The irregular contour of the cranium suggests craniosynostosis in a 24-month-old infant (left) and the relatively low density in both cerebral parenchyma was found(right); B: The dysplasia of gyrus in the right hemisphere and the corresponding porencephaly was found on CT image in a 24-month-old infant. The high-density hematoma was also found in the contralateral subdural space; C: The CT indicated the extent low density of both cerebral parenchyma in a 36-month-old infant. D: The absence of left frontal lobe in axial CT was found in a 48-month-old child. The subsequent follow-up demonstrated the barylalia with normal movement function; E: The giant gyrus in the right and the polygyria in left hemisphere on CT was found in a 60-month-old child. F: The dysplasia of left both frontal and parietal lobe was found on MRI in a 48-month-old infant. G: The polygyria was found in both the bilateral frontal and parietal lobe on axial MRI in a 48-month-old infant.

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