| Age group | Case numbers | Clinical indications | Outcomes |
| ≤ 1 year | 19 | Seizure(n=4),Head enlargement(n=4),Vomit(n=1),Neonatal asphyxia(n = 1),Muscle weakness strength(n=2),Unspecific indications(n=7) | Death(n =8),Visual dysfunction(n=1),Dyskinesia and aphasia(n=3),No severe neurological complications(n=1),Follow-up lost(n=6) |
| 1-3 years | 7 | Aphasia(n = 1),Muscle weakness strength(n = 1),Seizure(n = 1),Intracranial hemorrhage(n = 3),Unspecific indications(n = 1) | Dyskinesia and aphasia(n=3),No neurological complications(n=1),Follow-up lost(n=3) |
| >3 years | 10 | Dysgnosia(n=1),Muscle weakness strength(n=1),Dyskinesia(n=3),Seizure(n=3),Unspecific indications(n=2) | Developmental delay(n =1),Movement dysfunctional(n = 2),Speech impediment(n = 1),Follow-up lost(n =6) |
Fig 1 Imaging demonstrations of CNS malformations in the ≤ 1-year-old group A: CT revealed lissencephaly in a one-month-old infant; B: Dandy-walker malformation was found on sagittal MRI in a 1-month-old infant who died 3 months after birth; C: The cystic changes in bilateral cerebral parenchyma was found on MRI in a 2-month-old infant; D: The heavy hydrocephalus was found on CT in a 2-month-old infant who died after one-month treatment; E: The extent subdural effusion was found on CT for a 10-month-old infant who died one year after birth.
Fig 2 Imaging demonstrations of CNS malformations in the 1- to 3-year-old group and>3-year-old group A: The irregular contour of the cranium suggests craniosynostosis in a 24-month-old infant (left) and the relatively low density in both cerebral parenchyma was found(right); B: The dysplasia of gyrus in the right hemisphere and the corresponding porencephaly was found on CT image in a 24-month-old infant. The high-density hematoma was also found in the contralateral subdural space; C: The CT indicated the extent low density of both cerebral parenchyma in a 36-month-old infant. D: The absence of left frontal lobe in axial CT was found in a 48-month-old child. The subsequent follow-up demonstrated the barylalia with normal movement function; E: The giant gyrus in the right and the polygyria in left hemisphere on CT was found in a 60-month-old child. F: The dysplasia of left both frontal and parietal lobe was found on MRI in a 48-month-old infant. G: The polygyria was found in both the bilateral frontal and parietal lobe on axial MRI in a 48-month-old infant.