Fig 4 Zeocin induced endogenous dsRNA production in glioma and activated the PKR pathway A-C: Western blot detected the PKR and eIF2α protein expression in D54 cells treated with different concentrations of Zeocin, the dose-dependent upregulation effect of p-PKR and p-eIF2α was shown in the red box; D-F: Western blot detected the PKR and eIF2α protein expression in U251 cells treated with different concentrations of Zeocin, the dose-dependent upregulation effect of p-PKR and p-eIF2α was shown in the red box; HSV-1 was positive control, and all P values were compared with 0 μg/mL group. n=3, (1)P < 0.01, (2)P < 0.001, (3)P < 0.000 1, ns: Not significant.
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