Fudan University Journal of Medical Sciences

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Unilateral adrenal aldosteronoma with Klinefelter syndrome: one case report and literature review

Yue LI, Shu-fei ZANG, Yue-yue WU, Bing-bing ZHA, Guo-wei SHI, Jun ZHANG, Jun LIU

Fudan University Journal of Medical Sciences, 2025, 52(05): 752-758. DOI: 10.3969/j.issn.1672-8467.2025.05.019

Fig 1 Adrenal characteristics of the patient A and B: Non-contrast CT; C and D: Contrast-enhanced CT. A mass was observed in the left adrenal gland, suggestive of an adenoma, measuring approximately 24 mm×16 mm. The unenhanced CT attenuation value was 19 HU(the arrow in B), and the post-contrast CTattenuation values in 3 phases were approximately 35, 55 and 31 HU(the arrow in D). No abnormalities were observed in the right adrenal gland(the arrow in A and C).

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Fig 2 Peripheral blood karyotype analysis: 47, XXY[90]/46, XY[9] Karyotype analysis of 100 peripheral blood cells revealed 90 cells with a 47, XXY karyotype, indicating the presence of an extra X chromosome, and 9 cells with a normal 46, XY karyotype.
Fig 3 HE staining (A) and CYP11B2 immunohistochemical staining (B) of resected adrenal lesion The images in the right column were magnification of the images in the left column.

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