Fudan University Journal of Medical Sciences

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TAFRO syndrome: one case report and literature review

Man-man LI, Yun-hua HOU, Chen-chen WANG, Ming DING, Xiao-xiao WANG, Zheng WEI

Fudan University Journal of Medical Sciences, 2025, 52(02): 305-310. DOI: 10.3969/j.issn.1672-8467.2025.02.020

Fig 2 Temporal pathological changes of bone marrow fibrosis A: On the first day of admission to the hematology ward, bone marrow biopsy showed proliferation of bone marrow fibrous tissue (reticular fiber staining×40: MF1-MF2); B: On the 29th day of admission to the hematology ward, bone marrow biopsy showed no proliferation of bone marrow fibrous tissue (reticular fiber staining×10: negative).

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Fig 1 Chest and abdominal CT shows a small amount of bilateral pleural effusion, a small amount of pericardial effusion, A: Bilateral pleural effusions (right-sided depth: 3.7 cm, left-sided: 2.6 cm) with minimal pericardial effusion (fluid layer thickness: 0.7 cm); B: Ascites (scattered fluid-density opacities in the peritoneal cavity); C: Pelvic effusion (patchy fluid-density opacities with maximal measurements: 11.6 cm×7.9 cm). a small amount of abdominal effusion and a big amount of pelvic effusion
Fig 3 PET-CT shows enlarged lymph nodes with multiple increased FDG uptake throughout the body FDG: ¹⁸F-Fluorodeoxyglucose. Arrows indicated lymph nodes with increased FDG metabolism.
Fig 4 Lymph node biopsy specimen under low magnification Lymph node biopsy shows nodular distribution of lymphocytes at low magnification, atrophy of the germinal center, proliferation of cells in the mantle and marginal regions, and proliferation of blood vessels in the stroma, with some glassy changes (HE×10).
Fig 5 Lymph node biopsy shows patchy distribution of plasma cells under high magnification (HE×100)

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