Fudan University Journal of Medical Sciences

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Phenotypic evaluation of Ttc37 knockout mouse as type Ⅰ tricho-hepato-enteric syndrome model

Ming-ya LI, Xue-lin WANG, Ye WEI, Pei-hong YANG, Lei SUN

Fudan University Journal of Medical Sciences, 2024, 51(02): 249-256. DOI: 10.3969/j.issn.1672-8467.2024.02.016

Fig 1 Construction of Ttc37 knockout mouse A: Schematic diagram of the strategy used to generate Ttc37 knockout mice; B: PCR genotyping of Ttc37^+/+; CAG-Cre, Ttc37^flox/+; CAG-Cre, and Ttc37^flox/flox; CAG-Cre in mouse tails; C and D: Evaluation of Ttc37 mRNA and protein in mouse livers.

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Tab 1 sgRNAs and primer sequences used in experiments
Fig 2 The skin and hair phenotypes of ttc37 knockout mice A: Representative image for hair coat; B: Representative hematoxylin-eosin staining images of skin. Control: Ttc37^+/+; CAG-Cre mice. Model: Ttc37^flox/flox; CAG-Cre mice.
Fig 3 Immunodeficiency phenotype in Ttc37 knockout mice A: TD and TI antibody response; B: Spleen mass and spleen/body ratio; C: Representative hematoxylin-eosin staining images of spleen. Control: Ttc37^+/+; CAG-Cre mice. Model: Ttc37^flox/flox; CAG-Cre mice.
Fig 4 Ttc37 knockout mice did not have significant intestinal and hepatic phenotypes A-B: Representative hematoxylin-eosin staining images of GI and liver; C: Concentration of AST and ALT in serum. Control: Ttc37^+/+; CAG-Cre mice. Model: Ttc37^flox/flox; CAG-Cre mice.
Fig 5 The eye, hemoglobin and bladder phenotypes of Ttc37 knockout mice A: Representative image for cataract phenotype; B: Concentration of hemoglobin in the serum of mice; C: Mouse bladder weight; D: Representative hematoxylin-eosin staining images of bladder. Control: Ttc3^+/+; CAG-Cre mice. Model: Ttc37^flox/flox; CAG-Cre mice.

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