The protective effect of propofol on myocardium after cervical spinal cord injury in rats

XU Zhen-dongΔ;SHI Xue-yin;HE Xing-ying;Zou Zui;Li Ying-ke.

Fudan University Journal of Medical Sciences ›› 2008, Vol. 35 ›› Issue (5) : 711-0.

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Fudan University Journal of Medical Sciences ›› 2008, Vol. 35 ›› Issue (5) : 711-0.
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The protective effect of propofol on myocardium after cervical spinal cord injury in rats

  • XU Zhen-dong1Δ,SHI Xue-yin2,HE Xing-ying2,Zou Zui2,Li Ying-ke2.
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Abstract

Objective To study the protective effect of propofol on myocardium after cervical spinal cord injury(SCI)in rats. Methods A cervical laminectomy extending from C6-T1 was performed and the experimental acute cervical 7 spinal cord injury model was established by modified Allen’s method.Totally 96 male Sprague Dawley rats were randomly divided into three groups: control group(sham operation); lactate Ringer’s injection group(infusion with lactate Ringer’s injection at a rate of 12 mL&#8226;kg-1&#8226;h-1 over 1 hour after SCI); propofol group(infusion with propofol at a rate of 15 mg&#8226;kg-1&#8226;h-1 over 1 hour after SCI). At 1h after SCI, c-fos protein in myocardium was detected by immuno-histochemical methods. At 4h and 24h after SCI, we measured serum LDH,CK and CK-Mb level. At 72h, myocardial specimen was sampled from left ventricle to observe structure under light and electron microscope. Results c-fos protein expression and cardiac enzymes level in lactate Ringer’s injection group were higher than those in the control group and propofol group(P<0.05. Ultrastructure of myocardial tissue presented abnormal changes in SCI groups, but the changes in propofol group were milder. Conclusion High level spinal cord injury could induce

Key words

spinal cord injuries / propofol / myocardial enzymes / c-fos

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XU Zhen-dongΔ;SHI Xue-yin;HE Xing-ying;Zou Zui;Li Ying-ke. . The protective effect of propofol on myocardium after cervical spinal cord injury in rats [J]. Fudan University Journal of Medical Sciences, 2008, 35(5): 711-0
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