Preparation and quality control of mometasone furoate gel

REN Xiao-Wei;CAO Shi-Lei;CHEN Jun;CHEN En;JIANG Xin-Guo△

Fudan University Journal of Medical Sciences ›› 2008, Vol. 35 ›› Issue (5) : 707-0.

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Fudan University Journal of Medical Sciences ›› 2008, Vol. 35 ›› Issue (5) : 707-0.
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Preparation and quality control of mometasone furoate gel

  • REN Xiao-Wei, CAO Shi-Lei, CHEN Jun, CHEN En, JIANG Xin-Guo△
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Abstract

Objective To establish the preparation and a method of quality control of mometasone furoate intranasal gel. Methods The mometasone furoate intranasal gel was prepared by Xanthan gum as base material, the content of mometasone furoate was determined by ultraviolet spectrophotometry. Results The calibration curve was good linear in the range from 1 ug/mL to 100 ug/mL (r=0.9999). The average recovery was 100.6%. Conclusions The preparation of gel is simple. The quality of gel is stable and controlled. The new mometasone furoate gel is effective in allergic rhinitis.

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mometasone furoate / situ gel / HPLC

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REN Xiao-Wei;CAO Shi-Lei;CHEN Jun;CHEN En;JIANG Xin-Guo△. Preparation and quality control of mometasone furoate gel[J]. Fudan University Journal of Medical Sciences, 2008, 35(5): 707-0
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