Awake craniotomy: effects of target concentration of propofol infusion on awake time and adverse events
SHI Hong, LIANG Wei-min, ZHANG Jun
Author information+
Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China
{{custom_zuoZheDiZhi}}
{{custom_authorNodes}}
{{custom_bio.content}}
{{custom_bio.content}}
{{custom_authorNodes}}
Collapse
History+
Received
Revised
Published
2008-02-21
1900-01-01
2008-09-20
Issue Date
2008-09-20
Abstract
Objective To study the effects of different target concentration of propofol infusion on awake time and adverse events. Methods Sixty-two patients undergoing craniotomy were randomly assigned to four groups in which the propofol target concentration was set at 3.5, 4.0, 4.5 and 5.0μg/mL respectively after induction, and no more anesthetics were given besides increasing the concentration of propofol. So when the patients were asked to be waked up, the patients had been divided into 5 groups: 3.5,4.0,4.5,5.0 and >5.0μg/mL. Awake time and adverse events were recorded. Results Awake time of the patients in the 3.5μg/mL and 4.0μg/mL groups was significantly shorter than that in other groups. However, adverse events of the patients in the 3.5μg/mL group were significantly much more than those in other groups. Conclusions: Propofol target concentration has significant effects on awake time and adverse events, and 4μg/mL is a suitable propofol target concentration after induction.
SHI Hong;LIANG Wei-min�ZHANG Jun.
Awake craniotomy: effects of target concentration of propofol infusion on awake time and adverse events [J]. Fudan University Journal of Medical Sciences, 2008, 35(5): 651-0
PDF(416 KB)
