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Current status and prospects of malaria vaccine research based on bibliometric analysis
Xian ZHOU, Xue-lin HOU, Xin-yu WANG, Ji-bin XIN
Fudan University Journal of Medical Sciences ›› 2025, Vol. 52 ›› Issue (02) : 190-200.
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Current status and prospects of malaria vaccine research based on bibliometric analysis
Objective: To analyze the current status of malaria vaccine research from 2019 to 2024 by using bibliometric methods. Methods: Based on the Web of Science core collection database, we used VOSviewer to conduct a visual analysis of the publishing trends, publishing journals, international cooperation status, institutions and research hotspots of malaria vaccine research. Results: A total of 2 467 relevant articles were retrieved, and the annual number of publications showed a stable trend. The number of articles published by different countries/regions varied greatly, and the top effect was obvious. The United States published the most papers (1 032 articles, 41.83%).The international cooperation network reflected the regional collaborative relationships in malaria vaccine research, predominantly involving the United States, the United Kingdom, Australia, India and China. Through keyword co-occurrence clustering, the current research hotspots in the field of malaria vaccines were basic research on key sites and mechanisms of potential vaccines, clinical research on new vaccines, epidemiological studies on the impact of malaria vaccines on malaria transmission, etc. Conclusion: In recent years, malaria vaccine research has received sustained attention. The translation of clinical research on malaria vaccine was currently accelerating, and children and women were still the key groups of concern.
malaria / vaccine / bibliometric analysis / VOSviewer / research status {{custom_keyword}} /
Tab 1 Journals with more than 50 publications in the field of malaria vaccines area during 2019‒2024表 1 2019—2024年疟疾疫苗领域发文量>50篇的期刊 |
| No. | Periodical | Quantity | Average citation frequency | Impact factor（2023） | JCR quartile |
| 1 | Malar J | 152 | 5.84 | 2.4 | Q2/Q3 |
| 2 | Front Immunol | 146 | 9.76 | 5.7 | Q1 |
| 3 | Vaccine | 78 | 8.29 | 4.5 | Q2 |
| 4 | Sci Rep | 70 | 8.06 | 3.8 | Q2 |
| 5 | PLoS One | 66 | 6.29 | 2.9 | Q2 |
| 6 | Vaccines | 64 | 7.03 | 5.2 | Q1 |
| 7 | Front Cell Infect Microbiol | 58 | 6.07 | 4.6 | Q1/Q2 |
| 8 | NPJ Vaccines | 53 | 14.83 | 6.9 | Q1 |
Tab 2 The top 20 countries in the quantity of publishing malaria vaccines papers during 2019‒2024表 2 2019—2024年疟疾疫苗相关发文量排名前20位的国家 |
| No. | Country | Quantity（%） | Average citation frequency | No. | Country | Quantity（%） | Average citation frequency | |
| 1 | USA | 1 032（41.83） | 13.82 | 11 | Kenya | 127（5.15） | 13.13 | |
| 2 | UK | 433（17.55） | 15.62 | 12 | Ghana | 113（4.58） | 10.40 | |
| 3 | India | 235（9.53） | 10.91 | 13 | Japan | 109（4.42） | 8.14 | |
| 4 | Australia | 227（9.20） | 15.85 | 14 | Thailand | 90（3.65） | 6.44 | |
| 5 | China | 190（7.70） | 9.83 | 15 | Spain | 87（3.53） | 13.84 | |
| 6 | Germany | 189（7.66） | 15.99 | 16 | Denmark | 82（3.32） | 19.70 | |
| 7 | Netherlands | 159（6.45） | 16.84 | 17 | Canada | 80（3.24） | 14.55 | |
| 8 | France | 152（6.16） | 12.49 | 18 | Tanzania | 77（3.12） | 16.16 | |
| 9 | Switzerland | 137（5.55） | 15.76 | 19 | Belgium | 72（2.92） | 14.97 | |
| 10 | Brazil | 128（5.19） | 10.07 | 20 | Nigeria | 70（2.84） | 12.29 |
Fig 1 Social network of countries in the field of malaria vaccines junction(frequency≥5)during 2019 and 2024图 1 2019—2024年疟疾疫苗研究领域国家/地区的社会网络图（频率≥5次） |
Tab 3 Highly cited papers in malaria vaccines area during 2019‒2024(frequency≥80)表 3 2019—2024年疟疾疫苗高被引论文（被引次数≥80次） |
| No. | Title | Corrsponding author | Institute/Country | Year | Periodical | Citation frequency |
| 1 | Efficacy of a low-dose candidate malaria vaccine，R21 in adjuvant Matrix-M，with seasonal administration to children in Burkina Faso：a randomised controlled trial | Tinto H | Inst Rech Sci Sante，Burkina Faso | 2021 | Lancet | 188 |
| Hill AVS | Univ Oxford，UK | |||||
| 2 | RTS，S/AS01 vaccine（MosquirixTM）：an overview | Laurens MB | Univ Maryland，USA | 2020 | Hum Vacc Immunother | 182 |
| 3 | Outcomes of controlled human malaria infection after BCG vaccination | Sauerwein RW | Radboud Univ Nijmege，Netherlands | 2019 | Nat Commun | 144 |
| 4 | A new fractional SIRS-SI malaria disease model with application of vaccines，antimalarial drugs，and spraying | Kumar D | Univ Rajasthan，India | 2019 | Adv Differ Equ | 135 |
| 5 | T cell-mediated immunity to malaria | Harty JT | Univ Iowa，USA | 2019 | Nat Rev Immunol | 118 |
| 6 | Malaria vaccines since 2000：progress，priorities，products | Duffy PE | NIAID，USA | 2020 | NPJ Vaccines | 107 |
| 7 | Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention | Chandramohan D | London Sch Hyg & Trop Med，UK | 2021 | N Engl J Med | 87 |
| 8 | First-in-human，Randomized，Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC，A Vaccine Candidate to Prevent Pregnancy-associated Malaria | Nielsen MA | Univ Copenhagen & Copenhagen Univ Hosp，Denmark | 2019 | Clin Infect Dis | 85 |
| 9 | Mapping functional humoral correlates of protection against malaria challenge following RTS，S/AS01 vaccination | Alter G | Ragon Inst MGH Harvard & MIT，USA | 2020 | Sci Transl Med | 80 |
| Wille-Reece U | PATHs Malaria Vaccine Initiat，USA | |||||
| Jongert E | GSK Vaccine，Belgium | |||||
| 10 | Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years’ follow-up in children in Burkina Faso：a phase 1/2b randomised controlled trial | Hill AVS | Univ Oxford，UK | 2022 | Lancet Infect Dis | 80 |
| Tinto H | Inst Rech Sci Sante，Burkina Faso |
Fig 4 Network view of keywords plus co-occurrence in malaria vaccines research during 2019 and 2024图 4 2019—2024年疟疾疫苗相关研究关键词共现网络视图 |
| 1 |
WHO. World malaria report 2023[EB/OL]. (2023-11-30)[2024-5-27]. https://www.who.int/publications/i/item/9789240086173.
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国家传染病医学中心. 疟疾诊疗指南[J]. 中华传染病杂志, 2022, 40 (8): 449- 456.
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WHO. WHO malaria policy advisory group (MPAG) meeting: meeting report [EB/OL]. (2024-02-21)[2024-5-27]. https://iris.who.int/bitstream/handle/10665/341440/9789240027350-eng.pdf.
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余先明, 尤剑, 孟猛, 等. 国外冲突性健康信息研究热点与前沿分析[J]. 现代情报, 2024, 44 (11): 168- 177.
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作者贡献声明 周晛 数据整理，文献分析，论文撰写。侯雪林 数据检索和分析，论文撰写。王新宇 研究设计和指导，论文修改。辛继宾 数据检索和分析指导，论文修改。
利益冲突声明 所有作者均声明不存在利益冲突。
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Tab 1 Journals with more than 50 publications in the field of malaria vaccines area during 2019‒2024Tab 2 The top 20 countries in the quantity of publishing malaria vaccines papers during 2019‒2024
Fig 1 Social network of countries in the field of malaria vaccines junction(frequency≥5)during 2019 and 2024Fig 2 Cross-country collaborations visualization map of malaria vaccines area(frequency≥30)during 2019 and 2024Fig 3 Quantity, total link strength and total citations of the top 10 institutions in the field of malaria vaccines during 2019 and 2024Tab 3 Highly cited papers in malaria vaccines area during 2019‒2024(frequency≥80)Fig 4 Network view of keywords plus co-occurrence in malaria vaccines research during 2019 and 2024Fig 5 Time series graph of keywords in the field of malaria vaccines research during 2019 and 2024/
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