Research advances in the treatment of hepatic arterial infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC)
XU Shu-rong1,2, CHEN Rong-xin1,2
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1. Department of Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;
2. Liver Cancer Institute, Fudan University, Shanghai 200032, China
Hepatic arterial chemoembolization,molecular targeted therapy and immunotherapy are currently recommended treatments for advanced hepatocellular carcinoma (HCC).However,there is a lack of remedial treatment after these treatments are ineffective or failed.Some studies have found that hepatic artery infusion chemotherapy (HAIC) has a survival benefit in patients with advanced HCC,suggesting that HAIC may be a salvage treatment for the failure or ineffectiveness of various treatments.Although previous studies have shown that HAIC is effective in the treatment of advanced HCC,data from large randomized controlled clinical trials are missing.In order to make HAIC as a recommended treatment for advanced HCC,much more work needs to be done:HAIC to be compared with current standard treatments for advanced HCC;to delineate predictive indicators for efficacy of HAIC;to optimize and standardize HAIC treatment.This review aims to provide an introduction of the research progresses in clinical applications of HAIC treatment.
XU Shu-rong, CHEN Rong-xin.
Research advances in the treatment of hepatic arterial infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC)[J]. Fudan University Journal of Medical Sciences, 2019, 46(06): 814-818,823 https://doi.org/10.3969/j.issn.1672-8467.2019.06.016
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