胰腺癌与凝血相关因素的研究进展

李国平1,2 (综述),龚高全1,2,陈颐1,2,王小林1,2△(审校)

复旦学报(医学版) ›› 2018, Vol. 45 ›› Issue (01) : 106-112.

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复旦学报(医学版) ›› 2018, Vol. 45 ›› Issue (01) : 106-112. DOI: 10.3969/j.issn.1672-8467.2018.01.017
胰腺癌综述专栏

胰腺癌与凝血相关因素的研究进展

  • 李国平1,2 (综述),龚高全1,2,陈颐1,2,王小林1,2△(审校)
作者信息 +

Research progress of relationship between pancreatic cancer and blood coagulation factors

  • LI Guo-ping1,2, GONG Gao-quan1,2, CHEN Yi1,2, WANG Xiao-lin1,2△
Author information +
文章历史 +

摘要

目前广泛认为胰腺癌存在着一种内在的独特能力使大部分胰腺癌患者存在高凝状态,并易导致血栓形成。在下肢深静脉彩超检查时,超过50%的胰腺癌患者存在深静脉血栓。是什么导致了胰腺癌此种高凝状态,这种高凝状态与胰腺癌之间有何关系,对胰腺癌的侵袭、转移以及预后有何作用;如何应对这种高凝状态是值得研究的问题。本综述从胰腺癌的高凝状态产生的原因、机制,高凝状态对于胰腺癌发展和转移的作用,预防和治疗方面措施的研究进展进行讨论,并提出今后的研究方向。

Abstract

It has been widely considered that the pancreatic cancer has an inherent and unique ability to induce a hypercoagulable state that leads to clinically significant thrombosis.During examination of lower-limb venous with color doppler blood flow images,more than 50% of pancreatic cancer patients were found having deep vein thrombosis (DVT).The causes of the hypercoagulable state in pancreatic cancerare still partly understood now.Its relationship with invasion,metastasis and prognosis of pancreatic cancer also need further research.How to deal with this kind of hypercoagulable state is worthy of study.This article discusses changes of some main factors in clotting mechanism of pancreatic cancer.The progress of research on the prevention and treatment is expounded and the future research direction is also put forward.

关键词

胰腺癌 / 凝血机制 / 组织因子 / 血栓形成 / 高凝状态

Key words

pancreatic cancer / clotting mechanism / tissue factor / thrombosis / hypercoagulable state

引用本文

导出引用
李国平1,2 (综述),龚高全1,2,陈颐1,2,王小林1,2△(审校). 胰腺癌与凝血相关因素的研究进展[J]. 复旦学报(医学版), 2018, 45(01): 106-112 https://doi.org/10.3969/j.issn.1672-8467.2018.01.017
LI Guo-ping1,2, GONG Gao-quan1,2, CHEN Yi1,2, WANG Xiao-lin1,2△. Research progress of relationship between pancreatic cancer and blood coagulation factors[J]. Fudan University Journal of Medical Sciences, 2018, 45(01): 106-112 https://doi.org/10.3969/j.issn.1672-8467.2018.01.017

基金

上海市慈善基金会项目(Z-14/59)

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