H19基因在肿瘤研究领域的研究进展

王晓东1(综述) 王晓娟2 赵鹏飞1 陈文捷1 吴慧哲1 魏敏杰1△(审校)

复旦学报(医学版) ›› 2017, Vol. 44 ›› Issue (02) : 224.

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复旦学报(医学版) ›› 2017, Vol. 44 ›› Issue (02) : 224. DOI: 10.3969/j.issn.1672-8467.2017.02.017
综述

H19基因在肿瘤研究领域的研究进展

  • 王晓东1(综述) 王晓娟2 赵鹏飞1 陈文捷1 吴慧哲1 魏敏杰1△(审校)
作者信息 +

Research progress of H19 gene in the field of tumor research

  • WANG Xiao-dong 1, WANG Xiao-juan 2, ZHAO Peng-fei 1 , CHEN Wen-jie 1, WU Hui-zhe 1, WEI Min-jie 1△
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文章历史 +

摘要

自人的印迹基因群11P15.5被发现以来,已被证明其与人体各种生理异常密切相关。而作为最早被鉴定的印记基因之一的非编码RNA分子H19 (lncRNA H19),不仅由于其与Beckwith-Wiedemann综合征(BWS)、罗素因综合征(SRS)相关,而且H19能够派生miRNA675的印记基因,与多种肿瘤相关,可产生反义编码的lncRNA 91H (功能尚不清楚)而引起学者关注。本文将首次从H19基因的印记属性、SNP变异、lncRNA属性及其可能的作用机制信号轴等方面就H19基因在肿瘤发生进程中的研究现状作一综述。

Abstract

Since human imprinted genes in 11P15.5 was found, it had been proved that various human physiological abnormality associated with it. As one of the first identified imprinted non-coding RNA genes, more attention is paid to lncRNA H19 by many scholars not only because it's linked with Beckwith-Wiedemann syndrome (BWS) and Russell syndrome (SRS), but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding. This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects: imprinting feature, single nucleotide polymorphisms, lncRNA character and its possible action signal axis in cancer.

关键词

基因印记 / 肿瘤 / lncRNAH19 / miR675

Key words

gene imprinting / tumor / lncRNAH19 / miR675

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王晓东1(综述) 王晓娟2 赵鹏飞1 陈文捷1 吴慧哲1 魏敏杰1△(审校). H19基因在肿瘤研究领域的研究进展[J]. 复旦学报(医学版), 2017, 44(02): 224 https://doi.org/10.3969/j.issn.1672-8467.2017.02.017
WANG Xiao-dong 1, WANG Xiao-juan 2, ZHAO Peng-fei 1,CHEN Wen-jie 1, WU Hui-zhe 1, WEI Min-jie 1△. Research progress of H19 gene in the field of tumor research[J]. Fudan University Journal of Medical Sciences, 2017, 44(02): 224 https://doi.org/10.3969/j.issn.1672-8467.2017.02.017

基金

国家自然科学基金(81572898, 81402948)

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