目的 通过对猪心房间隔穿刺（atrial septum puncture，ASP）方法的改善，使操作更方便，心脏穿孔或心包积液的发生率更低，ASP更安全有效。方法 在心腔内超声心动图（intra-cardiac echocardiography，ICE）引导下，使用0.014英寸SION导丝的尾端对28只约克夏白猪进行ASP。应用SPSS 22.0 统计软件计算肺血流/全身血流平均值及平均ASP时间。术后4周观察房间隔穿刺孔闭合情况。结果 成功对28只约克夏白猪进行ASP，超声心动图提示房间隔有左向右分流，无并发症发生。平均Qp/Qs为1.3±0.2（中位数1.3，95%CI：1.3~1.4），ASP平均用时（40.6±7.3）s （中位数41.0 s，95%CI：37.8~43.3 s）。手术4周后，28只猪的房间隔穿刺孔均内皮化导致闭合。结论 在ICE引导下，使用0.014英寸SION导丝的尾端对约克夏白猪进行ASP安全且有效。
Abstract
Objective Improvement in the way of atrial septum puncture （ASP） in order to operate more conveniently， decrease complications and make ASP more safe and effective.Methods ASP was performed in 28 Yorkshire swines under intra-cardiac echocardiography （ICE） guidance with the end of a SION guidewire of 0.014 inch.Statistical analyses of average pulmonary/systemic blood flow and average ASP time were performed using SPSS 22.0. We observed the closure of ASP 4 weeks after surgery.Results ASP was successfully performed in 28 Yorkshire swines without complications. Ultrasound cardiography showed left to right shunt through atrial septum after ASP. The average Qp/Qs ratio was 1.3±0.2 （median 1.3，95%CI：1.3-1.4）. The average ASP time was （40.6±7.3） seconds （median 41 seconds，95%CI 37.8-43.3 seconds）. Four weeks after surgery， the ASP holes in 28 swines were endothelialized and closed.Conclusion It is safe and efficient for ASP using the end of 0.014 inch SION guidewire under ICE guidance in Yorkshire swines.
关键词
房间隔穿刺(ASP) /
SION导丝 /
心腔内超声心动图(ICE) /
猪
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Key words
atrial septal puncture （ASP） /
SION guidewire /
intra-cardiac echocardiography （ICE） /
swine
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中图分类号：
R-332，R541
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参考文献
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