髓样锌指蛋白1在卵巢癌中的表达及其与预后的关系

陈瑞芳, 岳荟然, 李文质, 鹿欣, 李俊

复旦学报(医学版) ›› 2021, Vol. 48 ›› Issue (05) : 592-597.

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复旦学报(医学版) ›› 2021, Vol. 48 ›› Issue (05) : 592-597. DOI: 10.3969/j.issn.1672-8467.2021.05.004
论著

髓样锌指蛋白1在卵巢癌中的表达及其与预后的关系

  • 陈瑞芳, 岳荟然, 李文质, 鹿欣, 李俊
作者信息 +

The expression and prognostic value of myeloid zinc finger 1 in ovarian cancer

  • CHEN Rui-fang, YUE Hui-ran, LI Wen-zhi, LU Xin, LI Jun
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摘要

目的 探索髓样锌指蛋白1(myeloid zinc finger 1,MZF1)在卵巢癌中的表达及其与预后的关系。方法 利用基因表达数据库(Gene Expression Ominus,GEO)GSE10971和GSE12172和癌症基因组数据库(The Cancer Genome Altas,TCGA),分析MZF1在正常输卵管上皮、低度恶性潜能的卵巢肿瘤(卵巢交界性肿瘤)和卵巢癌中的表达差异,并探讨其表达高低与卵巢癌预后的关系。同时,采用基因富集分析(gene set enrichment analysis,GSEA),探究MZF1高表达和MZF1低表达的卵巢癌患者相关信号通路的差异。结果 (1)MZF1在卵巢癌中的表达明显低于正常输卵管上皮和卵巢交界性肿瘤中的表达;(2)在达到满意瘤体减灭术的卵巢癌患者中,MZF1高表达的卵巢癌患者无病进展生存期和总生存期长;(3)GSEA提示在MZF1低表达的患者中,炎症反应相关基因、上皮间充质转化相关基因、血管生成相关基因和脂肪形成相关基因均显著富集。结论 MZF1在卵巢癌组织中呈低表达,高表达MZF1的卵巢癌患者预后好,提示其可能在卵巢癌中发挥抑癌基因的作用。

Abstract

Objectives To evaluate the expression and prognostic value of myeloid zinc finger 1 (MZF1) in ovarian cancer. Methods We first analyzed the differential expression of MZF1 among fallopian tube epitheliums, low malignant potential ovarian tumors (borderline ovarian tumor), and ovarian cancers using Gene Expression Ominus (GEO) database (GSE10971 and GSE12172 datasets).Then, we assessed the relationship between MZF1 expression and overall survival (OS) of ovarian cancer patients using GEO database and The Cancer Genome Altas (TCGA) database.Finally, gene set enrichment analysis (GSEA) was performed to identify the potential MZF1-associated signaling pathways in ovarian cancer patients. Results (1) MZF1 expression was decreased in ovarian cancers compared with that in fallopian tubes and low malignant potential ovarian tumors;(2) In optimally debulked ovarian cancer patients, increased expression of MZF1 was associated with improved progression free survival and overall survival;(3) GSEA indicated that the genes involved in inflammatory response, epithelial-to-mesenchymal transition, angiogenesis, and adipogenesis were strongly enriched in ovarian cancer tissues with relatively low expression of MZF1. Conclusion MZF1 expression was decreased in ovarian cancer tissues, and increased MZF1 expression was associated with a better clinical outcome. MZF1 may play a tumor-suppressive role in ovarian cancer.

关键词

卵巢癌 / 髓样锌指蛋白1(MZF1) / 预后 / 基因富集分析(GSEA)

Key words

ovarian cancer / myeloid zinc finger 1 (MZF1) / prognosis / gene set enrichment analysis (GSEA)

引用本文

导出引用
陈瑞芳, 岳荟然, 李文质, 鹿欣, 李俊. 髓样锌指蛋白1在卵巢癌中的表达及其与预后的关系[J]. 复旦学报(医学版), 2021, 48(05): 592-597 https://doi.org/10.3969/j.issn.1672-8467.2021.05.004
CHEN Rui-fang, YUE Hui-ran, LI Wen-zhi, LU Xin, LI Jun. The expression and prognostic value of myeloid zinc finger 1 in ovarian cancer[J]. Fudan University Journal of Medical Sciences, 2021, 48(05): 592-597 https://doi.org/10.3969/j.issn.1672-8467.2021.05.004
中图分类号: R737.31   

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基金

国家自然科学基金青年项目(81802596)
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