干细胞稳态和动员的自主神经调控研究进展

陈小燕, 李清梅, 季诗梦, 程婷婷, 周建, 陈翠翠, 苏枭, 宋元林

复旦学报(医学版) ›› 2020, Vol. 47 ›› Issue (03) : 448-455.

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复旦学报(医学版) ›› 2020, Vol. 47 ›› Issue (03) : 448-455. DOI: 10.3969/j.issn.1672-8467.2020.03.022
综述

干细胞稳态和动员的自主神经调控研究进展

  • 陈小燕1, 李清梅5, 季诗梦1, 程婷婷1, 周建1,2, 陈翠翠1,2, 苏枭5, 宋元林1,2,3,4
作者信息 +

The autonomic nervous regulation of stem cell homeostasis and mobilization

  • CHEN Xiao-yan1, LI Qing-mei5, JI Shi-meng1, CHENG Ting-ting1, ZHOU Jian1,2, CHEN Cui-cui1,2, SU Xiao5, SONG Yuan-lin1,2,3,4
Author information +
文章历史 +

摘要

干细胞是一类具有自我更新和多向分化潜能的细胞,参与机体的稳态维持和组织修复过程。干细胞的动员、归巢和组织定植受多种因素调控,尤其是自主神经系统调控。自主神经系统是一个复杂而精确的调控网络,其包括交感神经和副交感神经。本文就交感神经、副交感神经、神经肽对干细胞调控机制及其临床意义进行综述。

Abstract

Stem cells possess self-renewal capacity and multi-directional differentiation potential. It participates in maintaining homeostasis and tissue repair process. The mobilization,homing,and tissueresident of stem cells are regulated by multiple factors,especially the autonomic nervous system. Autonomic nervous system is a complex and precisely tuned network, which include the sympathetic nerve and parasympathetic nerve.This review summarizes the effect of sympathetic, parasympathetic nerve, and neuropeptide on stem cells and its clinical value.

关键词

干细胞 / 自主神经 / 肾上腺素 / 乙酰胆碱

Key words

stem cell / autonomic nervous / epinephrine / acetylcholine

引用本文

导出引用
陈小燕, 李清梅, 季诗梦, 程婷婷, 周建, 陈翠翠, 苏枭, 宋元林. 干细胞稳态和动员的自主神经调控研究进展[J]. 复旦学报(医学版), 2020, 47(03): 448-455 https://doi.org/10.3969/j.issn.1672-8467.2020.03.022
CHEN Xiao-yan, LI Qing-mei, JI Shi-meng, CHENG Ting-ting, ZHOU Jian, CHEN Cui-cui, SU Xiao, SONG Yuan-lin. The autonomic nervous regulation of stem cell homeostasis and mobilization[J]. Fudan University Journal of Medical Sciences, 2020, 47(03): 448-455 https://doi.org/10.3969/j.issn.1672-8467.2020.03.022
中图分类号: R338.8   

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基金

国家自然科学基金(81770075,81630001,81490533,81570028,81770039);上海市临床重点专科建设项目(呼吸病学);973国家重点基础研究发展计划(2015CB553404);科技部国家重点研发计划(2016YFC1304104);"重大新药创制"科技重大专项(2018ZX09201002-006)
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