CⅡTA表达与喉鳞状细胞癌(LSCC)患者预后的关系

薛乙, 汤迪, 翟长文, 袁存存, 衡宇, 周梁, 陶磊, 路丽明

复旦学报(医学版) ›› 2020, Vol. 47 ›› Issue (02) : 192-196,213.

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复旦学报(医学版) ›› 2020, Vol. 47 ›› Issue (02) : 192-196,213. DOI: 10.3969/j.issn.1672-8467.2020.02.009
论著

CⅡTA表达与喉鳞状细胞癌(LSCC)患者预后的关系

  • 薛乙1, 汤迪1, 翟长文2, 袁存存2, 衡宇1, 周梁1, 陶磊1, 路丽明3
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Relationship between CⅡTA expression and prognosis of patients with laryngeal squamous cell carcinoma (LSCC)

  • XUE Yi1, TANG Di1, ZHAI Chang-wen2, YUAN Cun-cun2, HENG Yu1, ZHOU Liang1, TAO Lei1, LU Li-ming3
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摘要

目的 探讨MHC-Ⅱ类反式激活蛋白(class Ⅱ trans-activator,CⅡTA)的表达水平与喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)患者预后的关系。方法 收集2013年9月至2015年6月于复旦大学附属眼耳鼻喉科医院行手术治疗的喉癌患者的病例资料及组织标本。根据纳入标准最终入组67例,采用免疫组织化学方法检测LSCC组织标本中CⅡTA的表达情况。采用χ2检验、Kaplan-Meier、Log-rank检验、Cox比例风险模型多因素回归方法对CⅡTA的表达水平与LSCC患者的临床特征、术后总生存期(overall survival,OS)之间的关系进行分析。利用GEPIA分析CⅡTA的表达与头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)预后的关系。结果 CⅡTA的表达与LSCC的病理分级、临床分期、年龄、性别等临床特征无明显相关性;Kaplan-Meier分析显示在LSCC患者中CⅡTA高表达较低表达的预后好(P<0.05);GEPIA分析显示HNSCC患者中CⅡTA高表达较低表达的预后好(P<0.05);Cox多因素回归分析显示饮酒、CⅡTA的表达、淋巴结转移是LSCC术后生存时间的独立影响因素。结论 CⅡTA表达与LSCC患者术后OS的关系密切,可作为预测LSCC患者预后的辅助指标之一。

Abstract

Objective To investigate the relationship between the expression level of MHC class Ⅱ trans-activator (CⅡTA) and the prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Methods We collected case data and tissue specimens of patients with laryngeal cancer underwent surgery in hospital from Sep.2013 to Jun.2015.According to the inclusion criteria,67 patients were enrolled in the study.The expression of CⅡTA in LSCC tissue samples was detected by immunohistochemistry. The relationship between the expression level of CⅡTA and the clinical features of LSCC patients and overall survival (OS) after surgery were analyzed by χ2 test,Kaplan-Meier,Log-rank test and Cox proportional hazard model.The relationship between the expression level of CⅡTA and the prognosis of head and neck squamous cell carcinoma (HNSCC) patients by GEPIA. Results The expression of CⅡTA was not associated with clinical features such as pathological grade,clinical stage,age and gender of LSCC (P>0.05).Kaplan-Meier analysis showed that among LSCC patients,CⅡTA high expression has a better prognosis than CⅡTA low expression (P<0.05).GEPIA analysis showed that CⅡTA high expression in patients with HNSCC had a better prognosis than CⅡTA low expression (P<0.05).Cox multivariate regression analysis showed that alcohol consumption and CⅡTA high expression and lymph node metastasis were independent factors influencing postoperative survival time of patients with LSCC. Conclusion CⅡTA expression is closely related to postoperative OS in patients with LSCC.It can be used as an auxiliary indexto predict the prognosis of patients with LSCC.

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薛乙, 汤迪, 翟长文, 袁存存, 衡宇, 周梁, 陶磊, 路丽明. CⅡTA表达与喉鳞状细胞癌(LSCC)患者预后的关系[J]. 复旦学报(医学版), 2020, 47(02): 192-196,213 https://doi.org/10.3969/j.issn.1672-8467.2020.02.009
XUE Yi, TANG Di, ZHAI Chang-wen, YUAN Cun-cun, HENG Yu, ZHOU Liang, TAO Lei, LU Li-ming. Relationship between CⅡTA expression and prognosis of patients with laryngeal squamous cell carcinoma (LSCC)[J]. Fudan University Journal of Medical Sciences, 2020, 47(02): 192-196,213 https://doi.org/10.3969/j.issn.1672-8467.2020.02.009
中图分类号: R767   

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基金

国家自然科学基金(81772878,30801283,30972691);上海市科委青年科技启明星项目(09QA1401000,10QA1405900,14411961900);上海市卫生系统优秀青年人才培养计划(XYQ2011055,XYQ2011015);上海市科委生物医药处西医类引导重点项目(14411961900);国家重点研发计划项目(2017YFA0104500)
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