Atherosclerosis is the main pathological basis of coronary heart disease.It is a complicated progress involved many factors,and the result of the interaction between genetic and environmental factors.In addition to factors such as age, gender, obesity,smoking,hypertension and diabetes,abnormal lipid metabolism is a particularly important factor in promoting the development of atherosclerosis.Nowadays,there is increasing evidence that non-coding RNA is involved in the regulation process and plays an important role in the lipid metabolism and formation of atherosclerosis.Especially,the RNA interference (RNAi) using small interfering RNA (siRNA) has achieved significant lipid-lowering effects not only in animal experiments,but also in clinical trials.This article reviewed influencing factors of lipid metabolism and related interventions on non-coding RNA level.
LIN Zhen-hao, TANGMin-na, HU Jia-lu, YAN Yan.
Research progress on non-coding RNA and blood lipid metabolism[J]. Fudan University Journal of Medical Sciences, 2020, 47(01): 122-127 https://doi.org/10.3969/j.issn.1672-8467.2020.01.021